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Selected Publications

2025

Marc A et al. Viral Dynamic Models During COVID‐19: Are We Ready for the Next Pandemic? CPT: Pharmacometrics & Systems Pharmacology 2025.

Mitard de Girardier M et al. Exposure history shapes SARS-CoV-2 viral dynamics in Non-Human Primates and provides insights into correlates of protection against infection and transmission. Philosophical Transactions of the Royal Society B: Biological Sciences 2025.

Nguyen BT et al. A Viroimmunologic Model to Characterize the Antiviral Effect of Molnupiravir in Outpatients Infected With SARS-CoV-2: Implication for Treatment Duration. Journal of Infectious Diseases 2025

2024

Vemparala B et al. Antiviral capacity of the early CD8 T-cell response is predictive of natural control of SIV infection: Learning in vivo dynamics using ex vivo data. PLoS Computational Biology 2024.

Zaaraoui H et al. Modelling the effectiveness of antiviral treatment strategies to  prevent household transmission of acute respiratory viruses. PLoS Computational Biology 2024.

Beaulieu M et al. Antiviral effect of Evusheld in COVID-19 hospitalized patients infected with pre-Omicron or Omicron variants: a modeling analysis of the randomized DisCoVeRy trial. Journal of Antimicrobial Chemotherapy 2024.

El Messaoudi et al. Effect of Peg-IFN on the viral kinetics of HDV infected patients treated with bulevirtide. JHEP reports 2024.

 

2023

Nguyen BT et al. Early administration of tecovirimat shortens the time to mpox clearance in a model of human infection. PLoS Biology 2023.

Lingas G et al. Neutralizing Antibody Levels as a Correlate of Protection Against SARS-CoV-2 Infection: A Modeling Analysis. Clinical Pharmacology and Therapeutics 2023.

Kerioui M et al. Nonlinear multilevel joint model for individual lesion kinetics and survival to characterize intra-individual heterogeneity in patients with advanced cancer. Biometrics 2023.

Clairon Q et al. Modeling the kinetics of the neutralizing antibody response against SARS-CoV-2 variants after several administrations of Bnt162b2. PLoS Computational Biology 2023.

Marc A et al. Impact of variants of concern on SARS-CoV-2 viral dynamics in non-human primates. PLoS Computational Biology 2023.

 

2022

Mitja O et al. Viral dynamics in patients with monkeypox infection: a prospective cohort study in Spain. The Lancet Infectious Diseases 2022.

El Messaoudi S et al. A semi-mechanistic model to characterize the long-term dynamic of HBV markers during treatment with lamivudine and Peg-IFN. Clinical Pharmacology and Therapeutics 2022.

Marlin R et al. Antiviral efficacy of favipiravir against Zika and SARS-CoV-2 viruses in non-human primates. Nature communications 2022.

Delattre R et al. Combination of in vivo phage therapy data with in silico model highlights key parameters for treatment efficacy. Cell Reports 2022.

Lingas G et al. Effect of remdesivir on viral dynamics in COVID-19 hospitalized patients: a modeling analysis of the randomized, controlled, open-label DisCoVeRy trial. Journal of Antimicrobial Chemotherapy 2022.

 

2021

Marc A et al. Quantifying the relationship between SARS-CoV-2 viral load and infectiousness. Elife 2021.

Maisonnasse P et al. COVA1-18 neutralizing antibody protects against SARS-CoV-2 in three preclinical models. Nature Communications 2021.

Gonçalves A et al. SARS-CoV-2 viral dynamics in non-human primates. PLoS Computational Biology 2021.

 

Néant et al. Modeling SARS-CoV-2 viral kinetics and association with mortality in hospitalized patients: results from the French Covid-19 cohort. PNAS 2021.

 

​​Czuppon P et al. Success of prophylactic antiviral therapy for SARS-CoV-2: predicted critical efficacies and impact of different drug-specific mechanisms of action. PLoS Computational Biology 2021.

2020

Lingas G et al. Lassa viral dynamics in non-human primates treated with favipiravir or ribavirin. PLoS Computational Biology 2020.

Gonçalves A et al. Timing of antiviral treatment initiation is critical to reduce SARS-CoV-2 viral load. Clinical Pharmacology & Therapeutics: PSP 2020.

Maisonnasse P et al. Hydroxychloroquine against SARS-CoV-2 infection in non-human primates. Nature 2020.

Kerioui M et al. Bayesian inference using Hamiltonian Monte-Carlo algorithm for nonlinear joint modelling in the context of cancer immunotherapy. Statistics in Medicine 2020.

2019

Madelain V et al. Modeling favipiravir antiviral efficacy against emerging viruses: from animal studies to clinical trials. CPT:PSP 2019.

Tardivon C et al . Association between tumor size kinetics and survival in urothelial carcinoma patients treated with atezolizumab: implication for patient’s follow-up. Clinical Pharmacology & Therapeutics 2019; 106: 810-820.

2018

Madelain V et al. Ebola viral dynamics in nonhuman primates: insights into virus immuno-pathogenesis and antiviral strategies. Nature Communications 2018; 9: 4013

Guedj J et al. Antiviral efficacy of favipiravir against Ebola virus: a translational study in cynomolgus macaques. PLoS Medicine 2018; 15(3): e1002535.

 

2017

Nguyen THT et al. The paradox of highly effective sofosbuvir-based combination therapy despite slow viral decline: can we still rely on viral kinetics? Scientific Report 2017; 7: e10233.

Best K et al. Zika plasma viral dynamics in non-human primates: insights into early infection and antiviral strategies. PNAS 2017; 114(33): 8847-8852.

Madelain V et al. Favipiravir pharmacokinetics in non-human primates: insights for future efficacy studies of haemorrhagic fever viruses. Antimicrobial Agents & Chemotherapy 2017; 61:e01305-16

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