ABOUT ME
I am a researcher in biostatistics/pharmacometrics at the French Institute of Health & Medical Research (Inserm), specialized in viral dynamics and antiviral treatment. My researches have theoretical and clinical objectives, such as understanding drug’s mechanism of action and optimizing their efficacy, in chronic (HIV, HBV) and acute emerging viral infections (SARS-CoV-2, Ebola, Nipah). I also apply the methods developed in virus dynamics to other fields of research, in particular bacterial dynamics (microbiota, phage therapy) or cancer therapy.
I work in the IAME laboratory devoted to infectious diseases, and located on the premises of Hospital Bichat campus, in the north of Paris. Together with Pr France Mentré, I am co-leading a group of pharmacometrics, biostatistics and clinical investigation in infectious diseases
EDUCATION/CURRICULUM
RESEARCH INTERESTS
Modeling the impact of antiviral treatments in SARS-CoV-2 infected individuals
PhD thesis of Aurélien Marc, funded by Bill & Melinda Gates fundation.
2012
Chargé de recherches (Researcher)
INSERM / Université de Paris
Favipiravir for the prevention and the treatment of emerging viral infections.
PhD thesis of Guillaume Lingas, funded by Université de Paris.
Development of a modeling framework to optimize combination therapy of new antiviral agents against Hepatitis B virus.
PhD thesis of Selma El Messaoudi, in collaboration with Annabelle Lemenuel-Diot, funded by Roche pharmaceuticals
2007 - 2009
Postdoctoral fellow
Bar-Ilan University (Tel-Aviv, Israel)
Director: Prof Avidan U. Neumann
2003 - 2006
PhD thesis
Université Bordeaux 2
Director: Daniel Commenges & Rodolphe Thiébaut
Modeling HIV/SIV controls after early anti-retroviral treatment.
Postdoc of Nadège Néant, funded by NIH.
Joint modeling to characterize the variability in response to immunotherapy treatments.
PhD thesis of Marion Kerioui, in collaboration with René Bruno (Genentech) & Solène Desmée (Univ. Tours), funded by Genentech (Cifre)
2000 - 2003
Ecole Nationale de la Statistique & de l'Analyse de l'Information (ENSAI)
2009 - 2012
Postdoctoral fellow
Los Alamos National Laboratory (New Mexico, USA)
Director: Alan S Perelson
Modeling the impact of antiviral treatment at the individual and populational levels
Postdoc of Hind Zaaraoui, in collaboration with Lulla Opatowski, funded by Orchestra (EU H2020)
2021
Directeur de recherches (Research Director)
INSERM / Université de Paris