ABOUT ME
I am a research scientist in biostatistics/pharmacometrics at the French Institute of Health & Medical Research (Inserm), specialized in infectious diseases and antiviral treatment. My researches have theoretical objectives, such as developing mathematical models to understand quantitative aspects of host/pathogen interaction. They also aim to impact clinical research by optimizing drug combination, dosing regimen and identify characteristics associated with a differential response to antiviral treatment.
My researches have initially focused on chronic viral infections (HIV, HBV, HCV) and have progressively shifted to acute emerging viral infections (SARS-CoV-2, viral hemorrhagic fever). I also apply the models and the statistical methods developed in virus dynamics to other fields of research, in particular bacterial dynamics (microbiota, phage therapy) and cancer.
I work in the INSERM IAME laboratory devoted to infectious diseases, and located on the premises of Hospital Bichat campus, in the north of Paris. Within IAME, I am leading a group named MOCLID devoted to modeling and clinical investigation in infectious diseases, gathering about 50 scientists, medical doctors and young researchers.
SUPERVISION
Mpox models of viral dynamics (since 2025)
Postdoc Thomas Bénéteau, funded by ANRS
Coinfection of viral respiratory viruses, from in vitro to in vivo analysess (since 2023)
PhD thesis of Clarisse Schumer, funded by ANR (Contrat Doctoral)
Correlates of protection in SARS-CoV-2 (since 2023)
PhD thesis of Adrien Mitard, funded by PEPR Santé Numérique (Contrat Doctoral), in collaboration with Mélanie Prague (INRIA)
Modeling the efficacy of antiviral strategies against variants of concerns of Sars-CoV-2: from general community to hospitalized patients (since 2022)
PhD thesis of Maxime Beaulieu, funded by Université Paris Cité (Contrat Doctoral)
Monkeypox infection and modeling (2022-2024)
Postdoc Bach Nguyen, funded by ANRS
Modeling the impact of antiviral treatment at the individual and populational levels (2022-2025)
Postdoc of Hind Zaaraoui, in collaboration with Lulla Opatowski, funded by Orchestra (EU H2020)
Repurposed drug therapy in emerging viral diseases (2019-2022)
Postdoc Guillaume Lingas, funded by Ecole de Recherche de l'INSERM
Interactions in gut flora during antibiotic treatment (2022-2024)
Postdoc of Carlos Olivares, cosupervised with Charles Burdet, funded by ANR Bla Impact
Modeling the impact of antiviral treatments in SARS-CoV-2 infected individuals (2020-2023)
PhD thesis of Aurélien Marc, funded by Bill & Melinda Gates fundation
Development of a modeling framework to optimize combination therapy of new antiviral agents against Hepatitis B virus (2020-2024).
PhD thesis of Selma El Messaoudi, in collaboration with Annabelle Lemenuel-Diot, funded by Roche pharmaceuticals
EDUCATION/CURRICULUM
2021
Directeur de recherche (Research Director)
INSERM / Université Paris Cité
2012
Chargé de recherche (Research Scientist)
INSERM / Université Paris Cité
2009 - 2012
Postdoctoral fellow
Los Alamos National Laboratory (New Mexico, USA)
Director: Alan S Perelson
2007 - 2009
Postdoctoral fellow
Bar-Ilan University (Tel-Aviv, Israel)
Director: Prof Avidan U. Neumann
2003 - 2006
PhD thesis
Université Bordeaux 2
Director: Daniel Commenges & Rodolphe Thiébaut
2000 - 2003
Ecole Nationale de la Statistique & de l'Analyse de l'Information (ENSAI)